Acid/Pepsin Promotion of Carcinogenesis in the Hamster Cheek Pouch

Carcinogenesis in the Hamster Cheek Pouch

Pouches from three experimental and one control animal were excised for analysis at various times during the first week and thereafter each week of carcinogen application (9,10-dimethyl-l ,~-benzanthracene) until the 131h week, at which time large tumors were present in all remaining aninmls. IIistologic progression from normal through inflanmmtion, uniform hyperplasia, localized premalignant h...

Placental glutathione S-transferase isoenzyme expression during promotion of two-stage hamster cheek-pouch carcinogenesis.

Glutathione S-transferases (GSTs) are the products of a multigene family. A well-established function of GSTs is to metabolize carcinogens by catalysing the conjugation of electrophilic substrates to glutathione. Whether placental GST (GST-P) is expressed during the promotion of two-stage hamster buccal-pouch mucosa (HBPM) carcinogenesis was investigated here, using 7,12-dimethylbenz[a]anthrace...

Antineoplastic effect of chlorpromazine in chemical carcinogenesis in the hamster cheek pouch.

Carcinogenesis in the hamster cheek pouch. II. Changes in enzymes of glucose-6-phosphate oxidation.

The activities of the enzymes, hexokinase, glucose-6-phosphate dehydrogenase, and phosphogluconate dehydrogenase were determined in extracts prepared from hamster cheek pouches which were being painted thrice weekly with 9,10-dimethyl-l,2-benzanthracene. Histology revealed five periods: I, no change, approximately 1 week; II, inflammation, 2d and 3d week; III, hyperplasia after the 3d week; IV,...

Effects of dimethyl sulfoxide on dimethylbenzanthracene-induced carcinogenesis in the hamster cheek pouch.

The studies demonstrated that the use of dimethyl sulfoxide (DMSO) as a vehicle for dimethylbenzanthracene in the produc tion of experimental tumors in the hamster cheek pouch, sig nificantly reduced the latent period for tumor production when compared to the usual mineral oil vehicle. No systemic or local changes could be attributed to the DMSO itself, and the mor phology of induced tumors was...